Document 0577
 DOCN  M9480577
 TI    Cerebral glial tumors and human immunodeficiency virus-1 infection. More
       than a coincidental association.
 DT    9410
 AU    Moulignier A; Mikol J; Pialoux G; Eliaszewicz M; Thurel C; Thiebaut JB;
       Hopital Tenon, Service de Neurologie, Paris, France.
 SO    Cancer. 1994 Jul 15;74(2):686-92. Unique Identifier : AIDSLINE
       MED/94306330
 AB    BACKGROUND. The authors describe the clinical and morphologic patterns
       in four patients with acquired immune deficiency syndrome (AIDS) who
       developed intracranial glial tumors. METHODS. This retrospective study
       reports 70 patients at various stages of human immunodeficiency virus-1
       (HIV-1) infection who underwent stereotactic brain biopsy for an
       intracerebral space-occupying lesion. RESULTS. Of these patients, four
       had glial tumors: one astroblastoma, two astrocytomas, and one
       glioblastoma. Glial tumors probably arise from a complex interplay of
       factors; possibilities include the activation of a dominant oncogene or
       viral inactivation of a tumor suppressor gene by a viral promoter (like
       the tat protein), impairment of immune defenses (which facilitates the
       growth of astrocytomas in acute lymphoblastic leukemia), production of
       cellular growth factors, cytokines, possible infection of glial cells by
       HIV, and the potentiation of a coinfectious agent. CONCLUSIONS. These
       cases illustrate that glial tumors should be considered in the
       differential diagnosis of brain masses in HIV-1 infection, especially
       because specific treatment for these tumors is available. Moreover, the
       occurrence of glial tumors in AIDS patients is not only an important
       event from a clinical point of view, but may also have implications for
       the pathogenesis of tumors in AIDS.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/GENETICS  Adult  Aged
       Astrocytoma/ETIOLOGY  Brain Neoplasms/*ETIOLOGY/GENETICS/PATHOLOGY
       Female  Glioblastoma/ETIOLOGY  Glioma/*ETIOLOGY/GENETICS/PATHOLOGY
       Human  Male  Middle Age  Retrospective Studies  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

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